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Precision bioactives — a new category

The healthy-aging actives brands can't buy anywhere else.

Trilliome makes precision bioactives — plant-derived molecules that steer the human gut microbiome with species-level precision. Active at milligrams, not grams. Shelf-stable without refrigeration. Formulable into capsules, drinks, bars or topicals.

For partners & formulators For investors

Got a minute? I'd love to know what brought you here.

Formulates into CapsulesDrinksBarsTopicals

Healthspan brands face an impossible trade-off.

You shouldn't have to choose.

  1. 01

    The actives with real biology are the hardest to work with

    The microbes most tied to cognitive and metabolic health are strict anaerobes that die in manufacturing. Live probiotics need cold chains. Conventional prebiotics work only at 5–10 gram doses and feed bacteria indiscriminately.

  2. 02

    The actives that are easy to formulate are commodities

    Differentiation-free, claim-free, margin-thin.

  3. 03

    So brands choose

    Efficacy or formulability, science or simplicity. And the healthspan claim that would actually move the category stays out of reach.

The species most linked to healthy aging already live in the gut. Getting to them is the hard part. the same named species, every time probiotics swallow live bacteria can’t reach them These species are strict anaerobes. A bottle, a shelf and a stomach all kill them. prebiotic fibre feed the whole community 5–10 g can’t choose them Fibre feeds everything in there at once. You get the whole community, or nothing. Trilliome switch on the ones already there ≤200 mg reaches exactly those Each product wakes named species, in place. Nothing has to survive the trip, so no cold chain. Milligrams, and it drops into any format.

The bacteria most closely linked to healthy aging cannot be put in a pill. They are already in you.

The first two outputs of an engine that keeps producing.

Precision gut-brain activator Shelf-stable · milligram-scale · any format Selectively induces a named four-species consortium of keystone gut bacteria — microbes whose benefits reach well beyond butyrate. Launches with gut-health claims; the gut–brain story follows as the evidence builds. Low-MW prebiotic fibre Water-soluble · metabolic-health path · lean GRAS A water-soluble prebiotic fibre that feeds the gut's short-chain fatty acid producers — with a metabolic-health claim path under active study.

We don't make an ingredient. We make a category.

At Trilliome's core is Teroka — a closed loop between a wetlab engine that measures how the gut ecosystem responds, and a computational engine that learns from it. Together they teach us how to steer the microbiome with high specificity.

TRI-01 and TRI-04 are the first two outputs. The platform is repeatable, it compounds, and it's the company — ingredients are the beginning, not the boundary.

generates response data designs the next experiments Wetlab engine turns biology into data Computational engine data science · ML precision bioactives TRI-01 · TRI-04
Teroka — two engines, tightly coupled, each making the other smarter.
7 Signed LOIs — incl. a top-4 global ingredient company
EPO Favourable Search Opinion on the cognitive indication
3× 2025 industry awards — EIT Food, ARDD, Probiota
0 Cold chain required — shelf-stable, formulates into any format

Donor-stool fermentation, ex-vivo human gut models. A mechanistic signal — the foundation for the human studies now planned, not a clinical outcome on its own. See the evidence →

Defining the category, in the open.

Our scientists write about what they're actually working on: the gut–brain axis, keystone species, and what "evidence" should mean for functional ingredients.

The brain is not sealed The immune cells defending your brain were supposed to last a lifetime. New human data shows they start being replaced around fifty, and the replacements are educated somewhere unexpected. A remote control for memory, hidden in the gut A new Nature paper shows an aging gut can drive memory loss on its own — and reverse it. The twist is which molecule does the damage. A GLP-1 drug treated depression without touching its receptor A GLP-1 drug relieved depression in mice with its receptor deleted. The effect ran through a single gut bacterium, not the brain. What the science says about the gut microbiome and mental health, and where it doesn't.